[Combination therapy at an early stage of the novel coronavirus infection (COVID-19). Case series and design of the clinical trial "BromhexIne and Spironolactone for CoronаvirUs Infection requiring hospiTalization (BISCUIT)"].
Identifieur interne : 000946 ( Main/Exploration ); précédent : 000945; suivant : 000947[Combination therapy at an early stage of the novel coronavirus infection (COVID-19). Case series and design of the clinical trial "BromhexIne and Spironolactone for CoronаvirUs Infection requiring hospiTalization (BISCUIT)"].
Auteurs : V Yu Mareev [Russie] ; Ya A. Orlova [Russie] ; E P Pavlikova [Russie] ; S T Matskeplishvili [Russie] ; Z A Akopyan [Russie] ; A G Plisyk [Russie] ; E M Seredenina [Russie] ; D A Asratyan [Russie] ; A V Potapenko [Russie] ; P S Malakhov [Russie] ; L M Samokhodskaya [Russie] ; E A Mershina [Russie] ; V E Sinitsyn [Russie] ; M M Bulanova [Russie] ; A A Fuks [Russie] ; Yu V. Mareev [Royaume-Uni] ; Yu L. Begrambekova [Russie] ; A A Kamalov [Russie]Source :
- Kardiologiia [ 0022-9040 ] ; 2020.
Descripteurs français
- KwdFr :
- Betacoronavirus (MeSH), Bromhexine (usage thérapeutique), Essais contrôlés randomisés comme sujet (MeSH), Hospitalisation (MeSH), Humains (MeSH), Infections à coronavirus (traitement médicamenteux), Moscou (MeSH), Pandémies (MeSH), Pneumopathie virale (traitement médicamenteux), Spironolactone (usage thérapeutique), Études prospectives (MeSH).
- MESH :
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Bromhexine, Spironolactone.
- Betacoronavirus, Essais contrôlés randomisés comme sujet, Hospitalisation, Humains, Moscou, Pandémies, Études prospectives.
English descriptors
- KwdEn :
- Betacoronavirus (MeSH), Bromhexine (therapeutic use), COVID-19 (MeSH), Coronavirus Infections (drug therapy), Hospitalization (MeSH), Humans (MeSH), Moscow (MeSH), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Prospective Studies (MeSH), Randomized Controlled Trials as Topic (MeSH), SARS-CoV-2 (MeSH), Spironolactone (therapeutic use).
- MESH :
- chemical , therapeutic use : Bromhexine, Spironolactone.
- geographic : Moscow.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- Betacoronavirus, COVID-19, Hospitalization, Humans, Pandemics, Prospective Studies, Randomized Controlled Trials as Topic, SARS-CoV-2.
Abstract
The article focuses on effective treatment of the novel coronavirus infection (COVID-19) at early stages and substantiates the requirement for antiviral therapy and for decreasing the viral load to prevent the infection progression. The absence of a specific antiviral therapy for the SARS-CoV-2 virus is stated. The authors analyzed results of early randomized studies using lopinavir/ritonavir, remdesivir, and favipiravir in COVID-19 and their potential for the treatment of novel coronavirus infection. Among the drugs blocking the virus entry into cells, the greatest attention was paid to the antimalaria drugs, chloroquine and hydroxychloroquine. The article addresses in detail ineffectiveness and potential danger of hydroxychloroquine, which demonstrated neither a decrease in the time of clinical recovery nor any improvement of prognosis for patients with COVID-19. The major objective was substantiating a possible use of bromhexine, a mucolytic and anticough drug, which can inhibit transmembrane serin protease 2 required for entry of the SARS-CoV-2 virus into cells. Spironolactone may have a similar feature. Due to its antiandrogenic effects, spironolactone can inhibit X-chromosome-related synthesis of ACE-2 receptors and activation of transmembrane serin protease 2. In addition to slowing the virus entry into cells, spironolactone decreases severity of fibrosis in different organs, including the lungs. The major part of the article addresses clinical examples of managing patients with COVID-19 at the University Clinic of the Medical Research and Educational Centre of the M. V. Lomonosov Moscow State University, including successful treatment with schemes containing bromhexine and spironolactone. In conclusion, the authors described the design of a randomized, prospective BISCUIT study performed at the University Clinic of the M. V. Lomonosov Moscow State University with an objective of evaluating the efficacy of this scheme.
DOI: 10.18087/cardio.2020.8.n1307
PubMed: 33155953
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Potapenko, A V" sort="Potapenko, A V" uniqKey="Potapenko A" first="A V" last="Potapenko">A V Potapenko</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Malakhov, P S" sort="Malakhov, P S" uniqKey="Malakhov P" first="P S" last="Malakhov">P S Malakhov</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Samokhodskaya, L M" sort="Samokhodskaya, L M" uniqKey="Samokhodskaya L" first="L M" last="Samokhodskaya">L M Samokhodskaya</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Mershina, E A" sort="Mershina, E A" uniqKey="Mershina E" first="E A" last="Mershina">E A Mershina</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Sinitsyn, V E" sort="Sinitsyn, V E" uniqKey="Sinitsyn V" first="V E" last="Sinitsyn">V E Sinitsyn</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Bulanova, M M" sort="Bulanova, M M" uniqKey="Bulanova M" first="M M" last="Bulanova">M M Bulanova</name><affiliation wicri:level="3"><nlm:affiliation>School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Fuks, A A" sort="Fuks, A A" uniqKey="Fuks A" first="A A" last="Fuks">A A Fuks</name><affiliation wicri:level="3"><nlm:affiliation>School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Mareev, Yu V" sort="Mareev, Yu V" uniqKey="Mareev Y" first="Yu V" last="Mareev">Yu V. Mareev</name><affiliation wicri:level="1"><nlm:affiliation>National Medical Research Centre for Therapy and Preventive Medicine, Moscow, Russia Robertson Centre for Biostatistics, Glasgow, Great Britain.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Medical Research Centre for Therapy and Preventive Medicine, Moscow, Russia Robertson Centre for Biostatistics, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Begrambekova, Yu L" sort="Begrambekova, Yu L" uniqKey="Begrambekova Y" first="Yu L" last="Begrambekova">Yu L. Begrambekova</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Kamalov, A A" sort="Kamalov, A A" uniqKey="Kamalov A" first="A A" last="Kamalov">A A Kamalov</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33155953</idno><idno type="pmid">33155953</idno><idno type="doi">10.18087/cardio.2020.8.n1307</idno><idno type="wicri:Area/Main/Corpus">000879</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000879</idno><idno type="wicri:Area/Main/Curation">000879</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000879</idno><idno type="wicri:Area/Main/Exploration">000879</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Combination therapy at an early stage of the novel coronavirus infection (COVID-19). Case series and design of the clinical trial "BromhexIne and Spironolactone for CoronаvirUs Infection requiring hospiTalization (BISCUIT)"].</title><author><name sortKey="Mareev, V Yu" sort="Mareev, V Yu" uniqKey="Mareev V" first="V Yu" last="Mareev">V Yu Mareev</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Orlova, Ya A" sort="Orlova, Ya A" uniqKey="Orlova Y" first="Ya A" last="Orlova">Ya A. Orlova</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Pavlikova, E P" sort="Pavlikova, E P" uniqKey="Pavlikova E" first="E P" last="Pavlikova">E P Pavlikova</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Matskeplishvili, S T" sort="Matskeplishvili, S T" uniqKey="Matskeplishvili S" first="S T" last="Matskeplishvili">S T Matskeplishvili</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Akopyan, Z A" sort="Akopyan, Z A" uniqKey="Akopyan Z" first="Z A" last="Akopyan">Z A Akopyan</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Plisyk, A G" sort="Plisyk, A G" uniqKey="Plisyk A" first="A G" last="Plisyk">A G Plisyk</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Seredenina, E M" sort="Seredenina, E M" uniqKey="Seredenina E" first="E M" last="Seredenina">E M Seredenina</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Asratyan, D A" sort="Asratyan, D A" uniqKey="Asratyan D" first="D A" last="Asratyan">D A Asratyan</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Potapenko, A V" sort="Potapenko, A V" uniqKey="Potapenko A" first="A V" last="Potapenko">A V Potapenko</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Malakhov, P S" sort="Malakhov, P S" uniqKey="Malakhov P" first="P S" last="Malakhov">P S Malakhov</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Samokhodskaya, L M" sort="Samokhodskaya, L M" uniqKey="Samokhodskaya L" first="L M" last="Samokhodskaya">L M Samokhodskaya</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Mershina, E A" sort="Mershina, E A" uniqKey="Mershina E" first="E A" last="Mershina">E A Mershina</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Sinitsyn, V E" sort="Sinitsyn, V E" uniqKey="Sinitsyn V" first="V E" last="Sinitsyn">V E Sinitsyn</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Bulanova, M M" sort="Bulanova, M M" uniqKey="Bulanova M" first="M M" last="Bulanova">M M Bulanova</name><affiliation wicri:level="3"><nlm:affiliation>School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Fuks, A A" sort="Fuks, A A" uniqKey="Fuks A" first="A A" last="Fuks">A A Fuks</name><affiliation wicri:level="3"><nlm:affiliation>School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Mareev, Yu V" sort="Mareev, Yu V" uniqKey="Mareev Y" first="Yu V" last="Mareev">Yu V. Mareev</name><affiliation wicri:level="1"><nlm:affiliation>National Medical Research Centre for Therapy and Preventive Medicine, Moscow, Russia Robertson Centre for Biostatistics, Glasgow, Great Britain.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Medical Research Centre for Therapy and Preventive Medicine, Moscow, Russia Robertson Centre for Biostatistics, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Begrambekova, Yu L" sort="Begrambekova, Yu L" uniqKey="Begrambekova Y" first="Yu L" last="Begrambekova">Yu L. Begrambekova</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Kamalov, A A" sort="Kamalov, A A" uniqKey="Kamalov A" first="A A" last="Kamalov">A A Kamalov</name><affiliation wicri:level="3"><nlm:affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author></analytic><series><title level="j">Kardiologiia</title><idno type="ISSN">0022-9040</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (MeSH)</term><term>Bromhexine (therapeutic use)</term><term>COVID-19 (MeSH)</term><term>Coronavirus Infections (drug therapy)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Moscow (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (drug therapy)</term><term>Prospective Studies (MeSH)</term><term>Randomized Controlled Trials as Topic (MeSH)</term><term>SARS-CoV-2 (MeSH)</term><term>Spironolactone (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Betacoronavirus (MeSH)</term><term>Bromhexine (usage thérapeutique)</term><term>Essais contrôlés randomisés comme sujet (MeSH)</term><term>Hospitalisation (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Moscou (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Spironolactone (usage thérapeutique)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bromhexine</term><term>Spironolactone</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Moscow</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Bromhexine</term><term>Spironolactone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Betacoronavirus</term><term>COVID-19</term><term>Hospitalization</term><term>Humans</term><term>Pandemics</term><term>Prospective Studies</term><term>Randomized Controlled Trials as Topic</term><term>SARS-CoV-2</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Betacoronavirus</term><term>Essais contrôlés randomisés comme sujet</term><term>Hospitalisation</term><term>Humains</term><term>Moscou</term><term>Pandémies</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The article focuses on effective treatment of the novel coronavirus infection (COVID-19) at early stages and substantiates the requirement for antiviral therapy and for decreasing the viral load to prevent the infection progression. The absence of a specific antiviral therapy for the SARS-CoV-2 virus is stated. The authors analyzed results of early randomized studies using lopinavir/ritonavir, remdesivir, and favipiravir in COVID-19 and their potential for the treatment of novel coronavirus infection. Among the drugs blocking the virus entry into cells, the greatest attention was paid to the antimalaria drugs, chloroquine and hydroxychloroquine. The article addresses in detail ineffectiveness and potential danger of hydroxychloroquine, which demonstrated neither a decrease in the time of clinical recovery nor any improvement of prognosis for patients with COVID-19. The major objective was substantiating a possible use of bromhexine, a mucolytic and anticough drug, which can inhibit transmembrane serin protease 2 required for entry of the SARS-CoV-2 virus into cells. Spironolactone may have a similar feature. Due to its antiandrogenic effects, spironolactone can inhibit X-chromosome-related synthesis of ACE-2 receptors and activation of transmembrane serin protease 2. In addition to slowing the virus entry into cells, spironolactone decreases severity of fibrosis in different organs, including the lungs. The major part of the article addresses clinical examples of managing patients with COVID-19 at the University Clinic of the Medical Research and Educational Centre of the M. V. Lomonosov Moscow State University, including successful treatment with schemes containing bromhexine and spironolactone. In conclusion, the authors described the design of a randomized, prospective BISCUIT study performed at the University Clinic of the M. V. Lomonosov Moscow State University with an objective of evaluating the efficacy of this scheme.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Automated" Owner="NLM"><PMID Version="1">33155953</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>10</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">0022-9040</ISSN><JournalIssue CitedMedium="Print"><Volume>60</Volume><Issue>8</Issue><PubDate><Year>2020</Year><Month>Sep</Month><Day>07</Day></PubDate></JournalIssue><Title>Kardiologiia</Title><ISOAbbreviation>Kardiologiia</ISOAbbreviation></Journal><ArticleTitle>[Combination therapy at an early stage of the novel coronavirus infection (COVID-19). Case series and design of the clinical trial "BromhexIne and Spironolactone for CoronаvirUs Infection requiring hospiTalization (BISCUIT)"].</ArticleTitle><Pagination><MedlinePgn>4-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.18087/cardio.2020.8.n1307</ELocationID><Abstract><AbstractText>The article focuses on effective treatment of the novel coronavirus infection (COVID-19) at early stages and substantiates the requirement for antiviral therapy and for decreasing the viral load to prevent the infection progression. The absence of a specific antiviral therapy for the SARS-CoV-2 virus is stated. The authors analyzed results of early randomized studies using lopinavir/ritonavir, remdesivir, and favipiravir in COVID-19 and their potential for the treatment of novel coronavirus infection. Among the drugs blocking the virus entry into cells, the greatest attention was paid to the antimalaria drugs, chloroquine and hydroxychloroquine. The article addresses in detail ineffectiveness and potential danger of hydroxychloroquine, which demonstrated neither a decrease in the time of clinical recovery nor any improvement of prognosis for patients with COVID-19. The major objective was substantiating a possible use of bromhexine, a mucolytic and anticough drug, which can inhibit transmembrane serin protease 2 required for entry of the SARS-CoV-2 virus into cells. Spironolactone may have a similar feature. Due to its antiandrogenic effects, spironolactone can inhibit X-chromosome-related synthesis of ACE-2 receptors and activation of transmembrane serin protease 2. In addition to slowing the virus entry into cells, spironolactone decreases severity of fibrosis in different organs, including the lungs. The major part of the article addresses clinical examples of managing patients with COVID-19 at the University Clinic of the Medical Research and Educational Centre of the M. V. Lomonosov Moscow State University, including successful treatment with schemes containing bromhexine and spironolactone. In conclusion, the authors described the design of a randomized, prospective BISCUIT study performed at the University Clinic of the M. V. Lomonosov Moscow State University with an objective of evaluating the efficacy of this scheme.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mareev</LastName><ForeName>V Yu</ForeName><Initials>VY</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Orlova</LastName><ForeName>Ya A</ForeName><Initials>YA</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pavlikova</LastName><ForeName>E P</ForeName><Initials>EP</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matskeplishvili</LastName><ForeName>S T</ForeName><Initials>ST</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akopyan</LastName><ForeName>Z A</ForeName><Initials>ZA</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plisyk</LastName><ForeName>A G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seredenina</LastName><ForeName>E M</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asratyan</LastName><ForeName>D A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Potapenko</LastName><ForeName>A V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malakhov</LastName><ForeName>P S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Samokhodskaya</LastName><ForeName>L M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mershina</LastName><ForeName>E A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sinitsyn</LastName><ForeName>V E</ForeName><Initials>VE</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bulanova</LastName><ForeName>M M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fuks</LastName><ForeName>A A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mareev</LastName><ForeName>Yu V</ForeName><Initials>YV</Initials><AffiliationInfo><Affiliation>National Medical Research Centre for Therapy and Preventive Medicine, Moscow, Russia Robertson Centre for Biostatistics, Glasgow, Great Britain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Begrambekova</LastName><ForeName>Yu L</ForeName><Initials>YL</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamalov</LastName><ForeName>A A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia School of Basic Medicine of the M. V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Kardiologiia</MedlineTA><NlmUniqueID>0376351</NlmUniqueID><ISSNLinking>0022-9040</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>27O7W4T232</RegistryNumber><NameOfSubstance UI="D013148">Spironolactone</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q1J152VB1P</RegistryNumber><NameOfSubstance UI="D001964">Bromhexine</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001964" MajorTopicYN="Y">Bromhexine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="Y">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009031" MajorTopicYN="N" Type="Geographic">Moscow</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="Y">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013148" MajorTopicYN="Y">Spironolactone</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>11</Month><Day>6</Day><Hour>12</Hour><Minute>11</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33155953</ArticleId><ArticleId IdType="doi">10.18087/cardio.2020.8.n1307</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Mareev, V Yu" sort="Mareev, V Yu" uniqKey="Mareev V" first="V Yu" last="Mareev">V Yu Mareev</name></region><name sortKey="Akopyan, Z A" sort="Akopyan, Z A" uniqKey="Akopyan Z" first="Z A" last="Akopyan">Z A Akopyan</name><name sortKey="Asratyan, D A" sort="Asratyan, D A" uniqKey="Asratyan D" first="D A" last="Asratyan">D A Asratyan</name><name sortKey="Begrambekova, Yu L" sort="Begrambekova, Yu L" uniqKey="Begrambekova Y" first="Yu L" last="Begrambekova">Yu L. Begrambekova</name><name sortKey="Bulanova, M M" sort="Bulanova, M M" uniqKey="Bulanova M" first="M M" last="Bulanova">M M Bulanova</name><name sortKey="Fuks, A A" sort="Fuks, A A" uniqKey="Fuks A" first="A A" last="Fuks">A A Fuks</name><name sortKey="Kamalov, A A" sort="Kamalov, A A" uniqKey="Kamalov A" first="A A" last="Kamalov">A A Kamalov</name><name sortKey="Malakhov, P S" sort="Malakhov, P S" uniqKey="Malakhov P" first="P S" last="Malakhov">P S Malakhov</name><name sortKey="Matskeplishvili, S T" sort="Matskeplishvili, S T" uniqKey="Matskeplishvili S" first="S T" last="Matskeplishvili">S T Matskeplishvili</name><name sortKey="Mershina, E A" sort="Mershina, E A" uniqKey="Mershina E" first="E A" last="Mershina">E A Mershina</name><name sortKey="Orlova, Ya A" sort="Orlova, Ya A" uniqKey="Orlova Y" first="Ya A" last="Orlova">Ya A. Orlova</name><name sortKey="Pavlikova, E P" sort="Pavlikova, E P" uniqKey="Pavlikova E" first="E P" last="Pavlikova">E P Pavlikova</name><name sortKey="Plisyk, A G" sort="Plisyk, A G" uniqKey="Plisyk A" first="A G" last="Plisyk">A G Plisyk</name><name sortKey="Potapenko, A V" sort="Potapenko, A V" uniqKey="Potapenko A" first="A V" last="Potapenko">A V Potapenko</name><name sortKey="Samokhodskaya, L M" sort="Samokhodskaya, L M" uniqKey="Samokhodskaya L" first="L M" last="Samokhodskaya">L M Samokhodskaya</name><name sortKey="Seredenina, E M" sort="Seredenina, E M" uniqKey="Seredenina E" first="E M" last="Seredenina">E M Seredenina</name><name sortKey="Sinitsyn, V E" sort="Sinitsyn, V E" uniqKey="Sinitsyn V" first="V E" last="Sinitsyn">V E Sinitsyn</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Mareev, Yu V" sort="Mareev, Yu V" uniqKey="Mareev Y" first="Yu V" last="Mareev">Yu V. Mareev</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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